Database : HANSEN Search on : HANSENIASE DIMORFA [Subject descriptor] References found : 262 [refine] Displaying: 1 .. 20   in format [Detailed]

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Id: 19948 Author: Ganapati, R; Pai, V. V; Shroff, H. J; Gandewar, Kailas. Title: Rate of decline in bacterial index in leprosy; observations after three different chemotherapeutic interventions. Source: Int. J. Lepr;65(2):264-266, Jun. 1997. tab, graf. Descriptors: Hanseníase Dimorfa/quimioter Hanseníase Dimorfa/microbiol Hanseníase Virchowiana/quimioter Hanseníase Virchowiana/microbiol Rifampina/uso terap Ofloxacino/uso terap Location: BR191.1

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Id: 19947 Author: Pavithran, K; Satish, T. C. Title: Dapsone-induced motor polyneuropathy in a patient with leprosy. Source: Int. J. Lepr;65(2):262-263, Jun. 1997. . Descriptors: Hanseníase Dimorfa/quimioter Dapsona/ef adv Dapsona/uso terap Doença dos Neurônios Motores/ind quim Doença dos Neurônios Motores/diag Limits: Humanos Masculino Feminino Location: BR191.1

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Id: 19933 Author: Soebono, Haryanto; Giphart, Marius J; Schreuder, Geziena M. T; Klatser, Paul R; Vries, Rene R. P. de. Title: Associations between HLA-DRB1 alleles and leprosy in an Indonesian population. Source: Int. J. Lepr;65(2):190-196, Jun. 1997. tab. Abstract: To investigate whether the susceptibility to leprosy (type), subclinical infection with Mycobacterium leprae and the antibody response against M. leprae-specific antigens are associated with HLA-DR phenotypes sequence-specific oligonucleotide HLA-DRB1 and DQA1 typing and antibody assays have been performed in 79 leprosy patients (41 TT/BT and 38 LL/BL) and 50 healthy controls from a Javanese population in Yogyakarta, Indonesia. DRB1*02 was associated with LL/BL [odds ratio (OR) 2.54, 95% confidence interval (CI) 0.97-9.78, p = 0.037 and attributable risk (AR) 41.5%] but not with TT/BT leprosy (p > 0.05). HLA-DRB1*12 was negatively associated with leprosy (either LL/BL or TT/BT [OR 0.33-0.35, p < 0.05, prevented fraction (PF) 58.8%-65.3%]. No significant association was found between HLA-DRB1 or DQA1 type, anti-M. leprae antibody level and subclinical infection with M. leprae. These data indicate that in this population susceptibility to lepromatous leprosy is associated with HLA-DRB1*02, while resistance to leprosy is associated with HLA-DRB1*12. These associations are not paralleled with associations of the same HLA types with anti-M. leprae antibody level. Finally, the results of this study also support the notion that infection with M. leprae per se is not associated with HLA-DRB1 or DQA1 alleles. (AU)^ien. Descriptors: Hanseníase Dimorfa/genet Hanseníase Virchowiana/genet Hanseníase Tuberculóide/genet Antígenos HLA-DQ/genet Antígenos HLA-DR/genet Location: BR191.1

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Id: 19932 Author: Klatser, Paul R; Janson, Anneke M; Thole, Jelle E. R; Buhrer, Samira; Bos, Corinne; Soebono, Hardyanto; Vries, Rene R. P. de. Title: Humoral and cellular immune reactivity to recombinant M. leprae antigens in HLA-Typed leprosy patients and healthy controls. Source: Int. J. Lepr;65(2):178-189, Jun. 1997. tab, graf. Abstract: In our search for Mycobacterium leprae antigens that might specifically induce immunity or immunopathology, we have tested both humoral and cellular immune reactivity against purified recombinant M. leprae antigens in 29 paucibacillary (PB), 26 multibacillary (MB) leprosy patients, and 47 matched healthy contacts. The following M. leprae antigens were tested: 2L-1 (65L-1, GroEl-1), 2L-2 (65L-2, GroEl-2), 4L (SoDA), 43L, 10L (B) and 25L (Sra). The individuals were also typed for HLAD-RB1 and DQB1 in order to see whether leprosy status and/or immune reactivity to these antigens might be associated with certain HLA types. We also tested sera from another 48 patients before, during and after multidrug therapy (MDT) to study the relationship between antibody reactivity to recombinant M. leprae antigens and MDT. Antibody titers to the four recombinant M. leprae antigens tested and to D-BSA were higher in MB patients compared to PB patients and healthy controls, and declined with treatment. From a diagnostic or monitoring point of view none of the recombinant antigens seemed to be an improvement over D-BSA, mainly due to the lower sensitivity. IgG subclasses were measured in positive sera of untreated patients. These were mainly of the IgG1 and IgG3 subclasses, but subclass diversity was also observed and antigen dependent: all four subclasses could be detected against 10L (B), only IgG1 and IgG3 against 43L and only IgG1 against 25L and 2L-1. Cellular immune reactivity against the purified recombinant M. leprae antigens was measured in a lymphocyte stimulation test (LST). As for M. leprae, there was an inverse correlation between antibody and T-cell reactivity. However, the number of LST responders to recombinant antigens was much lower than to M. leprae. The 43L antigen was recognized most often (19%-24% of individuals tested) and more often than the 10L (B) antigen (10%-12%). No clear correlation was observed with leprosy type or protection and, in general, M. leprae nonresponders were also negative with recombinant antigens. Finally, we confirmed that HLA-DRB1*02 is associated with leprosy in this population, and we observed an association between DQB1*0601 and lepromatous leprosy. The number of positive individuals was too small to allow a meaningful analysis of the relationship between HLA type and immune reactivity. Although these data do not allow a conclusion as to one of these purified recombinant antigens being either protection or disease related, the antigen-dependent IgG subclass diversity warrants further study on antigen-specific qualitative differences in immune reactivity that may be relevant for the outcome of an infection with M. leprae. (AU)^ien. Descriptors: Hanseníase Dimorfa/sangue Hanseníase Dimorfa/imunol Hanseníase Virchowiana/sangue Hanseníase Virchowiana/imunol Hanseníase Tuberculóide/sangue Hanseníase Tuberculóide/imunol Location: BR191.1

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Id: 19931 Author: Richard, Bruce M; Corry, Peter R. Title: Cervical branch of the facial nerve in leprosy. Source: Int. J. Lepr;65(2):170-177, Jun. 1997. tab. Abstract: This study demonstrates that the platysma is occasionally palsied in leprosy and that this only occurs when the facial nerve already has some other palsy. That there needs to be a facial palsy before there can be a platysma palsy is strongly suggested, in that there was no case of an isolated platysma palsy. Patients, regardless of age or other factors, could mimic a platysma contraction. This obviates the need for electrical testing to examine for a platysma palsy. It also means that a nonfunctioning platysma on clinical examination is, in fact, a palsied platysma. While lagophthalmos is regularly examined for, and any obvious facial paresis would be noticed, less severe forms of facial muscle paresis will only be found if formally examined for. The mechanism whereby the facial nerve is involved in leprosy is not clarified, but our findings suggest that proximal spread of a lesion that began in the zygomatico-temporal branches and reaches to the facial nerve trunk is more likely than new lesions developing de novo in other peripheral facial nerve branches. That the primary lesion is within the facial nerve trunk in all cases but we only see the frequent zygomatic sequelae due to secondary factors is not excluded. (AU)^ien. Descriptors: Hanseníase Dimorfa/diag Hanseníase Virchowiana/diag Hanseníase Tuberculóide/diag Hanseníase/diag Paralisia Facial/diag Limits: Humanos Masculino Feminino Location: BR191.1

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Id: 19929 Author: Kochar, Dhanpat Kumar; Gupta, Dharam Veer; Sandeep, Chauhan; Halwai, Mahendra; Kumawat, Banshi Lal. Title: Study of brain stem auditory-evoked potentials (BAEPs)and visual-evoked potentials (VEPs) in leprosy. Source: Int. J. Lepr;65(2):157-165, Jun. 1997. tab. Abstract: A study of brain stem auditory-evoked potentials (BAEPs) and visual-evoked potentials (VEPs) was done on 25 newly diagnosed patients with leprosy whose diagnosis was confirmed by skin biopsy. The results were compared with 25 age- and sex-matched healthy controls. In BAEPs the important observations were the prolonged latency of wave V in 13 (52%), delayed interpeak latency (IPL) of wave I-III in 5 (20%) cases, of wave III-V in 12/25 (40%), suggesting a conduction abnormality of the VIII cranial nerve in its peripheral part, in its nucleus and in its connection in the brain stem. In VEPs, a delayed peak latency of major positive potential (P100) was seen in 20 cases (80%; 11/13, 84.6% TT; 7/10, 70% LL; 2/2, 100% BL), suggestive of subclinical optic nerve involvement. The BAEPs and VEPs were both abnormal in 10 cases (40%; 3/13, 23% TT; 5/10, 50% LL; 2/2, 100% BL). Conduction abnormalities of the central nervous system (CNS) were observed more frequently in lepromatous leprosy, as in other forms of peripheral neuropathy such as hereditary motor sensory neuropathy type I (HMSN I). There is a fair possibility of similar multiple demyelinating lesions in the CNS also, as is seen in leprous peripheral neuropathy. This hypothesis requires further strengthening by an extensive study of multimodality evoked potentials with magnetic resonance imaging in the patients. Histopathological and immunofluorescent studies of autopsy material of the brain can also contribute significantly to solve the dilemma. (AU)^ien. Descriptors: Hanseníase Dimorfa/fisiopatol Hanseníase Virchowiana/fisiopatol Hanseníase Tuberculóide/fisiopatol Limits: Humanos Masculino Feminino Location: BR191.1

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Id: 19920 Author: Frankel, Richard I. Title: Regarding Ebenezer, et al. 's MB nerve histology in clinically diagnosed BT leprosy patients. Source: Int. J. Lepr;65(1):99-100, Mar., 1997. . Descriptors: Hanseníase Dimorfa/clas Hanseníase Dimorfa/diag Hanseníase Tuberculóide/clas Hanseníase Tuberculóide/diag Location: BR191.1

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Id: 19913 Author: Chaudhury, Sachin; Hajra, Sunil Kumar; Mukerjee, Ashutosh; Saha, Bibbuti; Majumdar, Vibek; Chattapadhya, Debasis; Saha, Kunal. Title: Immunotherapy of lepromin-negative borderline leprosy patients with low-dose convit vaccine as an adjunct to multidrug therapy; a six-year follow-up study in Calcutta. Source: Int. J. Lepr;65(1):56-62, Mar., 1997. tab. Abstract: The present report, which describes management of lepromin-negative borderline leprosy patients with low-dose Convit vaccine, is an extension of our earlier study on the treatment of lepromatous leprosy patients with low-dose Convit vaccine as an adjunct to multidrug therapy (MDT). The test Group I, consisting of 50 lepromin-negative, borderline leprosy patients, were given low-dose Convit vaccine plus MDT. The control group II consisted of 25 lepromin-negative, borderline leprosy patients given BCG vaccination plus MDT and 25 lepromin-negative, borderline leprosy patients given killed Mycobacterium leprae (human) vaccine plus MDT. The control group III consisted of 50 lepromin-positive, borderline leprosy patients not given any immunostimulation but given only MDT. Depending upon the lepromin unresponsiveness, the patients were given one to four inoculations of the various antileprosy vaccines and were followed up every 3 months for 2 years for clinical, bacteriological and immunological outcome. All patients belonging to the test and control groups showed clinical cure and bacteriological negativity within 2 years. However, immunologic potentiation, assessed by lepromin testing and the leukocyte migration inhibition test (LMIT), was better in the test patients receiving low-dose Convit vaccine plus MDT than in the control patients receiving BCG vaccine plus MDT or killed M. leprae vaccine plus MDT or MDT alone. But the capacity of clearance bacteria (CCB) test from the lepromin granuloma showed poor bacterial clearance in the test patients. However, there was no relapse during 6 years of follow up. Two mid-borderline (BB) patients had severe reversal reactions with lagophthalmos and wrist drop during immunotherapy despite being given low-dose Convit vaccine. (AU)^ien. Descriptors: Hanseníase Dimorfa/quimioter Hanseníase Dimorfa/terap Mycobacterium leprae/imunol Limits: Humanos Masculino Feminino Location: BR191.1

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Id: 19912 Author: Barrera, Silvia de la; Finiasz, Marta; Fink, Susana; Valdez, Raul; Bottasso, Oscar; Balina, Luis Maria; Sasiain, Maria del Carmen. Title: Differential development of CD4 and CD8 cytotoxic T cells (CTL) in PBMC across the leprosy spectrum IL-6 with IFN-gamma or IL-2 generate CTL in multibacillary patients. Source: Int. J. Lepr;65(1):45-55, Mar., 1997. tab, graf. Abstract: In the present study we evaluated the contribution of CD4 and CD8 T cells on the antigen-specific cytotoxic activity induced by whole Mycobacterium leprae in leprosy patients and normal controls (N) as well as the modulation of this activity by some cytokines. Peripheral blood mononuclear cells (PBMC) from N or from leprosy patients were stimulated with antigen in the presence or absence of cytokines for 7 days. M. leprae-stimulated PBMC were depleted of CD4 or CD8 antigen-bearing cells and employed as effector cells in a 4-hr [31Cr]-release assay against autologous M. leprae-pulsed macrophages. Our results demonstrate that both CD4 and CD8 T cells contribute to M. leprae-induced cytotoxic activity, with differences observed in paucibacillary (PB) and multibacillary (MB) patients. CD8-mediated cytotoxic activity is higher than that of CD4 cells in PB patients, while in MB patients CD4 cytotoxicity is predominant. Our data also demonstrate that the generation of CD4 and CD8 cytotoxic T lymphocytes (CTL) can be modulated differentially by interleukin-4 (IL-4), IL-6, gamma interferon (IFN-gamma), or IL-2. Although MB patients developed the lowest CTL response, cytokines such as IL-6 plus IL-2 or IFN-gamma were able to generate both CD4 and CD8 cytotoxic T cells from MB patients. In PB patients, IL-6 plus IFN-gamma displayed the highest stimulation on CD8 effector cells. Thus, an important role may be assigned to IL-6, together with IL-2 or IFN-gamma, in the differentiation of M. leprae-specific CTL effector cells. (AU)^ien. Descriptors: Linfócitos T CD4-Positivos/imunol Linfócitos T CD8-Positivos/imunol Hanseníase Dimorfa/imunol Hanseníase Virchowiana/imunol Hanseníase Tuberculóide/imunol Location: BR191.1

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Id: 19911 Author: Carsalade, Georges-Yves de; Wallach, Daniel; Spindler, Edith; Pennec, Jean; Cottenot, Francois; Flageul, Beatrice. Title: Daily multidrug therapy for leprosy; results of a fourteen-year experience. Source: Int. J. Lepr;65(1):37-44, Mar., 1997. graf. Abstract: Between 1980 and 1994, 67 new or relapsing leprosy patients were treated by daily administered multidrug regimens. Tuberculoid patients (23 TT/BT) received either bitherapy [rifampin + dapsone or clofazimine (RMP + DDS or CLO)] or tritherapy [RMP + DDS and/or CLO and/or ethionamide (ETH)] until clinical cure. Lepromatous patients (44 BB/BL/LL) received tritherapy (RMP + DDS and/or CLO and/or ETH) at least until bacteriological negativity. Of the 23 tuberculoid patients only one patient (5%) was cured at 6 months and about 70% needed between 6 and 24 months of treatment to obtain clinical cure (mean 19.5 months). In the 44 lepromatous patients, the achievement of bacteriological negativity was significantly linked to the initial bacterial index (BI), and it occurred after 2 to 7 years (mean 66.5 months) of multidrug therapy (MDT). The average BI decrease per year was 1.1+ during the first year, 0.9+ the second year, and then < 0.5+ per year. Reactional states significantly (p < 0.01) influenced the BI course: reversal reactions (RR) accelerated while erythema nodosum leprosum (ENL) delayed the BI decrease. Three of the 23 (13%) tuberculoid and 19 of the 44 (43%) lepromatous patients (p < 0.02) exhibited a RR and 18 of 44 (41%) lepromatous patients had ENL during MDT. A late RR (LRR) was observed in 1 (5%) and 6 (17%) of our tuberculoid and lepromatous patients, respectively, and 3 (8%) of our lepromatous patients suffered post-MDT ENL. No confirmed relapse has been observed within a follow-up period of 6 months to 7 years and 3 months [59 person-years at risk (PYR)] for TT/BT patients and of 4 months to 5 years and 10 months (100 PYR) for BB/BL/LL patients. When compared to the recommended WHO/MDT, it appears that daily MDT does not increase the clinical or the bacteriological cure rates either at 6 months in paucibacillary tuberculoid patients or at 2d years in multibacillary lepromatous patients. Moreover, as does the WHO/MDT, our regimens show a high frequency of reactional states both during and after treatment. This fact constitutes the main new problem of the actual treatment of leprosy. (AU)^ien. Descriptors: Hanseníase Dimorfa/quimioter Hanseníase Virchowiana/quimioter Hanseníase Tuberculóide/quimioter Limits: Humanos Masculino Feminino Location: BR191.1

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Id: 19876 Author: Fiallo, Paolo; Nunzi, Enrico; Cardo, Paolo P. Title: Beta2-Glycoprotein I- dependent anticardiolipin antibodies as risk factor for reactions in borderline leprosy patients. Source: Int. J. Lepr;66(3):387-388, Sept. 1998. . Descriptors: Hanseníase Dimorfa/imunol Hanseníase Dimorfa/patol Glicoproteínas/imunol Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1998/pdf/v66n3/v66n3cor01.pdf / en Location: BR191.1

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Id: 19875 Author: Ebenezer, Gigi J; Gnanaraj, Lionel; Ebenezer, Mannan; Job, Charles K. Title: Lepromatous orchitis associated with seminoma. Source: Int. J. Lepr;66(3):385-386, Sept. 1998. ilus. Descriptors: Seminoma/etiol Seminoma/patol Hanseníase Dimorfa/compl Hanseníase Virchowiana/compl Orquite/compl Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1998/pdf/v66n3/v66n3clinot.pdf / en Location: BR191.1

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Id: 19870 Author: Roche, Paul W; Theuvenet, Wim J; Le Master, Joseph W; Butlin, C. Ruth. Title: Contribution of type 1 reactions to sensory and motor function loss in borderline leprosy patients and the efficacy of treatment with prednisone. Source: Int. J. Lepr;66(3):340-347, Sept. 1998. tab. Abstract: The changes in nerve function tests in 297 new leprosy patients over an average period of 30 months were measured. The impact of type 1 reactions (T1R) on sensory and voluntary muscle function was measured by standard tests. Sensory function was improved in patients with single episodes of cutaneous T1R, but not improved in patients with neural T1R or with multiple episodes of either kind of T1R. Patients over 40 years of age improved less than younger patients, and patients admitted for treatment of T1R improved more than those treated as outpatients. These data point to a need to find better regimens for the treatment of nerve damage in T1R. (AU)^ien. Descriptors: Hanseníase Dimorfa/quimioter Hanseníase Dimorfa/fisiopatol Neurônios Motores/fisiol Neurônios Eferentes/fisiol Prednisolona/uso terap Limits: Humanos Masculino Feminino Criança Adolescente Adulto Idoso Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1998/pdf/v66n3/v66n3a04.pdf / en Location: BR191.1

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Id: 19868 Author: Rea, Thomas H; Sieling, Peter A. Title: Delayed-type hypersensitivity reactions followed by erythema noodosum leprosum. Source: Int. J. Lepr;66(3):316-327, Sept. 1998. tab. Abstract: Reported herein are 13 borderline lepromatous (BL) or subpolar lepromatous (LLs) patients who presented with or developed delayed-type hypersensitivity (DTH) reactions after initiation of antibacterial therapy, but who subsequently developed erythema nodosum leprosum (ENL), the DTH to ENL group. During the same time, three LLs patients had ENL followed by relapse-associated DTH, a significant (p < 0.05) difference in sequence of the two conditions. The DTH to ENL group had statistically significant higher biopsy indexes at the time of diagnosis of the DTH reaction compared with two DTH control groups, 7 multibacillary patients presenting with DTH reactions and 15 BL or LLs who developed DTH reactions after starting treatment but had no ENL. DTH-associated histologic changes were less well developed in the DTH to ENL group than in either of the two control groups. In the DTH to ENL group, 77% required prednisone in addition to thalidomide to achieve a complete remission in contrast to only 10% of 21 ENL clinical controls. In the DTH to ENL group, the classical histologic ENL pattern was present in only 31% of these patients, in contrast to 88% of 33 ENL histologic controls. In 9 of 9 of the DTH to ENL patients studied, after the ENL remitted, Mycobacterium leprae-sonicate-stimulated lymphocyte transformation tests gave stimulation indexes within the range of our tuberculoid (TT) and borderline tuberculoid (BT) patients, in contrast to absent responses in 6 ordinary, longterm-treated patients who had had ENL. (AU)^ien. Descriptors: Hanseníase Dimorfa/quimioter Hanseníase Dimorfa/imunol Hanseníase Virchowiana/quimioter Hanseníase Virchowiana/imunol Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1998/pdf/v66n3/v66n3a02.pdf / en Location: BR191.1

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Id: 19766 Author: Job, Charles K; Path, FRC. Title: Nerve damage in leprosy. Source: Int J Lepr;57(2):532-539, June 1989. . Descriptors: Hanseníase Dimorfa/compl Hanseníase Dimorfa/patol Hanseníase Virchowiana/compl Hanseníase Virchowiana/patol Hanseníase Tuberculóide/compl Hanseníase Tuberculóide/patol Hanseníase/compl Hanseníase/patol Limits: Humanos Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1989/pdf/v57n2/v57n2soalec01.pdf / en Location: Br191.1

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Id: 19761 Author: Patnaik, Jaya Krishna; Saha, Prafulla Kumar; Satpathy, Sanjav Kumar; Das, Bhabani Sankar; Bose, Tarit Kumar. Title: Hepatic morphology in reactional states of leprosy. Source: Int J Lepr;57(2):499-505, June 1989. ^bilus. Abstract: Liver function tests and liver biopsies were studied in 23 leprosy patients in reaction and 10 without reaction. The liver biopsies in leprosy patients with reaction showed exudative lesions, epithelioid and tuberculoid granulomas, and foam-cell granulomas. Portal vasculitis was encountered in a few cases. Neutrophilic infiltration into the foam-cell granulomas was seen in a few cases of lepromatous (LL) leprosy with reaction. In six cases of borderline (BL, BB and BT) leprosy with reaction, a spectrum of lesions bearing footprints of exudative lesions were seen evolving into epithelioid-cell granulomas. Foam-cell granulomas and tuberculoid and epithelioid granulomas along with exudative lesions were encountered in two cases on individual biopsy strips. An altered albumin-to-globulin ratio was the chief functional derangement observed in these cases. The spectrum of changes observed in borderline leprosy with reaction could be discrete steps in the evolution of upgrading reaction^ien. Descriptors: Hanseníase Dimorfa/compl Hanseníase Dimorfa/patol Hanseníase Virchowiana/compl Hanseníase Virchowiana/patol Hanseníase Tuberculóide/compl Hanseníase Tuberculóide/patol Limits: Humanos Masculino Feminino Criança Adolescente Adulto Meia-Idade Idoso Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1989/pdf/v57n2/v57n2a08.pdf / en Location: Br191.1

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Id: 19760 Author: Rangdaeng, Samreung; Scollard, David M; Suriyannon, Vinai; Smith, Trevor; Thamprasert, Kamthorn; Theetranont, Choti. Title: Studies of human leprosy lesions in situ using suction induced blisters 1. Cellular components of new, uncomplicated lesions. Source: Int J Lepr;57(2):492-498, June 1989. ^btab, ^bgraf. Abstract: The cellular contents of blisters induced by suction over new, uncomplicated leprosy lesions, and in the skin of cured, control patients, have been examined with enzyme- and immuno-histochemical staining over a period of 4 days. The total cellularity of the blisters varied over a wide range, not correlated with the type of leprosy. Mononuclear cells predominated at all times studied, with nearly equal percentages of monocytes and T lymphocytes. The T-helper: suppressor ratio was significantly greater in BT than in BL and LL lesions at 48 hr. Suction blisters offer a painless, quantitative, reproducible, multiple-sampling method for obtaining cells from the cutaneous infiltrates of leprosy for phenotyping or functional analysis^ien. Descriptors: Hanseníase Dimorfa/patol Hanseníase Virchowiana/patol Hanseníase Tuberculóide/patol Hanseníase/patol Limits: Humanos Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1989/pdf/v57n2/v57n2a07.pdf / en Location: Br191.1

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Id: 19754 Author: Katoch, Kiran; Ramu, Gopal; Ramanathan, Usha; Sengupta, Utpal; Sharma, Vishnu D; Shivannavar, Channappa T; Katoch, Vishwa M. Title: Results of a modified WHO regimen in highly bacilliferous BL/LL patients. Source: Int J Lepr;57(2):451-457, June 1989. ^bgraf, ^btab. Abstract: regimen consisting of 600 mg of rifampin once a month, 100 mg of clofazimine on alternate days, and 100 mg of dapsone daily was used in 56 untreated, highly bacillated borderline lepromatous/lepromatous (BL/LL) patients with an average bacterial index (BI) of 4.45. Treatment was continued until skin-smear negativity. After 2 years of therapy, none of the patients had become smear negative and the average BI was 2.56. There was no growth on inoculation of skin-tissue biopsies in the normal mouse foot pad after 6 months of therapy. Bacillemia was still detectable in 11/50 patients, and significant ATP levels were detected in Mycobacterium leprae from skin-tissue biopsies in 16% of the cases. After 3 years of therapy, three patients had become smear negative. The average BI was 1.30. None of the patients had detectable bacillemia, and 5% of the cases showed detectable ATP levels in M. leprae from tissue biopsies. After 4 years of therapy, 41.7% of the patients had become smear negative. The average BI was 0.66, and no ATP was detected in any of the purified bacillary suspensions. The fall in BI was accelerated, and more patients on continued treatment became negative earlier compared to those having treatment for a limited duration, as reported by others^ien. Descriptors: Clofazimina/admin Clofazimina/uso terap Dapsona/admin Dapsona/uso terap Hanseníase Dimorfa/microbiol Hanseníase Virchowiana/microbiol Limits: Humanos Adolescente Adulto Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1989/pdf/v57n2/v57n2a01.pdf / en Location: Br191.1

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Id: 19549 Author: Sharma, Pankaj; Kar, Hemant K; Kaur, Harvinder; Misra, Radhey S; Mukherjee, Ashok; Mukherjee, Rama; Rani, Rajni. Title: Induction of lepromin positivity and immunoprophylaxis in household contacts of multibacillary leprosy patients: a pilot study with a candidate vaccine, Mycobacterium w. Source: Int. J. Lepr;68(2):136-142, Jun., 2000. tab. Abstract: We screened 487 household contacts of multibacillary (MB) patients for evidence of disease and their lepromin status. From the 444 results available, 302 (68.02%) were lepromin positive and 142 (31.98%) were lepromin negative on initial testing. The initial lepromin status as assessed in the group of 54 contacts having disease at the outset showed 24 out of 46 (52.2%) to be lepromin positive and 22 of 46 (47.8%) to be lepromin negative. In the same group, among 24 lepromin positives, 22 (91.7%) had paucibacillary (PB) and 2 (8.3%) had multibacillary (MB) disease; among the lepromin negatives, 12 (54.5%) had PB and 10 (45.5%) had MB disease. Out of 72 initially lepromin-negative contacts administered Mycobacterium w vaccine and followed up, the cumulative percentages show that 53 (73.6%) converted to positivity after a single dose, 10 (87.5%) after a second dose and 67 (93.1%) after the third dose. The incidence of new cases with leprosy was 8 out of 231 (3.46%) among lepromin-positive contacts and 5 out of 93 (5.38%) among lepromin-negative contacts administered Mycobacterium w vaccine. Among 231 lepromin-positive contacts, the new cases occurred in those with a 1+ and 2+ lepromin response only, and no case occurred among 51 contacts with a 3+ lepromin response. The incidence among lepromin-positive contacts in this study (3.46%) was similar to the observations in two other studies: 3.2% by Dharmendra, et al. and 6.9% by Chaudhary, et al. However, the incidence among lepromin-negative contacts administered Mycobacterium w vaccine was significantly lower than that observed among lepromin-negative contacts not administered any vaccination in the other two studies (14.1% by Dharmendra, et al. and 29.0% by Chaudhary, et al.). To conclude, although a study of small sample size, the preliminary evaluation indicates that administration of Mycobacterium w vaccine seems to have the potential to reduce the incidence of leprosy among household contacts of leprosy patients. More explicit results about the vaccine will be available from the ongoing field trials in Kanpur Dehat in the near future. (AU)^ien. Descriptors: Mycobacterium leprae/genet Mycobacterium leprae/imunol Hanseníase Dimorfa/imunol Hanseníase Virchowiana/imunol Hanseníase Tuberculóide/imunol Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/2000/pdf/v68n2/v68n2a03.pdf / en Location: BR191.1

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Id: 19470 Author: Martelli, Celina M. T; Stefani, Mariane M. A; Gomes, Maria Katia; Rebello, Paula F. B; Peninni, Silmara; Narahashi, Kasue; Maroclo, Ana Lucia O; Costa, Mauricio B; Silva, Simonne A; Sacchetim, Sylvana C; Nery, Jose Augusto C; Salles, Ana Maria; Gillis, Thomas P; Krahenbuhl, James L; Andrade, Ana Lucia S. S. Title: Single lesion paucibacillary leprosy: baseline profile of the Brazilian Multicenter Cohort Study. Source: Int. J. Lepr;68(3):247-257, Sept., 2000. tab, graf, mapa. Abstract: In Brazil, there is little information about the clinical and epidemiological characteristics of paucibacillary, single skin lesion leprosy patients (SSL-PB). Only recently has the official notification system distinguished leprosy patients with a single lesion as a clinical entity, for whom the single-dose ROM (rifampin, ofloxacin and minocycline) regimen has been recommended. In this paper, we describe the baseline clinical features and the immunological background of a multicenter cohort of SSL-PB leprosy cases enrolled between December 1997-1998. Patients were recruited at health centers located in the following regions: Southeast = Rio de Janeiro; North = Amazon and Rondônia states and Center-West = Goiás state. Eligible cases were newly detected, untreated single-lesion leprosy patients without thickened nerve involvement, and were assessed by clinical, bacilloscopic and histopathological exams. The Mitsuda skin test and anti-PGL-I serology (ELISA) were also performed. Of the 299 SSL-PB leprosy patients, 259 (86.6%) fulfilled the criteria for single-dose ROM intervention. Our results showed that patients recruited from different sites had similar features, considering the clinical and immunological profiles. There was a predominance of adults (mean age 32.4; S.D. = 16.0), and a BCG scar was detected in 76.7% of the children (< or = 15 years old). Only 7 cases were diagnosed as the multibacillary type, representing less than 3% of the patients being misclassified. Our data indicate that in Brazil SSL-PB case ascertainment based on clinical and bacilloscopic criteria can be accurately defined under a routine control program; 75.0% of SSL-PB cases were Mitsuda positive (> or = 5 mm) and seropositivity for anti-PGL-I was detected in 17.3% of the patients. These data are compatible with effective cell-mediated immunity and low bacillary load, suggesting favorable clinical outcomes for most SSL-PB participants of this cohort. (AU)^ien. Descriptors: Hanseníase Dimorfa/fisiopatol Hanseníase Virchowiana/fisiopatol Hanseníase Tuberculóide/fisiopatol Hanseníase/fisiopatol Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/2000/pdf/v68n3/v68n3a01.pdf / en Location: BR191.1

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